Is Prolactin Mitogenic for Mammary Epithelium?
نویسندگان
چکیده
منابع مشابه
The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium.
The cytokine hormones prolactin and erythropoietin mediate tissue-specific developmental outcomes by activating their cognate receptors, prolactin receptor (PrlR) and erythropoietin receptor (EpoR), respectively. The EpoR is essential for red blood cell formation, whereas a principal function of PrlR is in the development of the mammary gland during pregnancy and lactation [Ormandy, C., et al. ...
متن کاملThe mammary epithelium is composed of a luminal epithelium and a basal layer containing myoepithelial cells
In adult females, the mammary epithelium is organized in two layers, a luminal epithelium and a basal layer, consisting of myoepithelial cells. Undifferentiated precursors of both luminal and myoepithelial cells are also believed to be basally localized. The mammary epithelium bilayer is surrounded by a basement membrane embedded in connective tissue. In the fully differentiated mammary gland, ...
متن کاملDuctal barriers in mammary epithelium
Tissue barriers play an integral role in the biology and pathobiology of mammary ductal epithelium. In normal breast physiology, tight and adherens junctions undergo dynamic changes in permeability in response to hormonal and other stimuli, while several of their proteins are directly involved in mammary tumorigenesis. This review describes first the structure of mammary ductal epithelial barri...
متن کاملProlactin and murine mammary tumorigenesis: a review.
It is unequivocal that prolactin is an influential hormone in murine mammary tumorigenesis. The Berenblum hypothesis (7), a well-known theoretical model of tumorigenesis that depicts this oncogenic process as a two-step mechanism, i.e., initiation and promotion, is a conceptual scheme in which the action of prolactin in mammary tumorigenesis may be understood. According to this conceptual model...
متن کاملThe role of prolactin in mammary carcinoma.
The contribution of prolactin (PRL) to the pathogenesis and progression of human breast cancer at the cellular, transgenic, and epidemiological levels is increasingly appreciated. Acting at the endocrine and autocrine/paracrine levels, PRL functions to stimulate the growth and motility of human breast cancer cells. The actions of this ligand are mediated by at least six recognized PRL receptor ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1972
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.69.7.1693